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He and his family moved to Texas in 1910. In 1927, he opened the Pinkston Clinic Hospital, which was the only operating clinic serving the African American community. He was the first of five African American doctors on the staff of St. Paul Hospital, where he remained until his death in 1961.

Named after Dr. Lee Gresham Pinkston, Sr., Pinkston High School opened on November 15, 1964.

School Division/Feeder Pattern:
Schools Division 3-Pinkston High School Feeder Pattern